The combination of bortezomib (velcade), pulsed dexamethasone and weekly cyclophosphamide (CVD) in relapsed/refractory myeloma patients induces high overall (75%) and complete (31%) response rates compared to velcade/dexamethasone (overall 47%, CR 5%) and velcade alone (overall 27%, CR 0%). The newly described monoclonal antibody By114 has been used with flow cytometry to investigate the status of the 90-kD glycosylphosphatidyl-inositol (GPI)-anchored component of CD66 (CD66c) on neutrophils from nine patients with paroxysmal nocturnal hemoglobinuria (PNH), seven with aplastic anemia/PNH, and 63 with aplastic anemia (AA) and a negativ... Clinical and morphologic characteristics of hairy cell leukemia at 11 patients have been analyzed. University of Arkansas for Medical Sciences, Centre Hospitalier Universitaire de Dijon, Haemato-oncology/Stem Cell Transplantation, A mathematical model of cell equilibrium and joint cell formation in multiple myeloma. Case 24: Striking Lymphocytosis in a 2-year-old Girl. © 2008-2021 ResearchGate GmbH. Through her mum, a nurse and midwife, she learned that integrity and doing the right thing are at the core of good nursing practice . Between April 1985 and June 1998, 251 patients, 59 (23%) with RD were entered into a ST program comprised of infusional chemotherapy (IC) with VAMP/C-VAMP (vincr... From 5/95 to 5/00, outcome of 67 patients (M:42, F:25,age:40yr) who received alloPBSCT was compared with 80(M:48, F:32,age:37yr) who received allo-BMT between I/ 90 and 1/00. Monica Else. Between April 1985 and June 1998, 251 patients, 59 (23%) with RD were entered into a ST program comprised of infusional chemotherapy (IC) with VAMP/C-VAMP (v... ABLC (Abelcet, The Liposome Company) is a ribbon-shaped liposomal formulation of amphotericin B consisting of dimyristoyl-phosphatidylcholine and dimyristoylphosphatidylglycerol in a 7:3 molar ratio which is especially concentrated in pulmonary tissue. These tests can include: Find out more about haematology diagnostics. Biography. Dr Rao is a Consultant Medical Oncologist specializing in gastrointestinal cancers and cancers of unknown primary within the Gastrointestinal Unit at the Royal Marsden Hospital. S godišnjeg skupa Global Myeloma Action Network. Between 1990 and 1944, 52 newly diagnosed patients with primary (n = 47) or therapy-related (n = 5) acute myeloid leukemia (AML) under the age of 55 years received an induction chemotherapy protocol (designated BF12) consisting of idarubicin ([IDA] 5 mg/m2), high-dose cytarabine ([HD-Ara-C] 2 mg/m2 per 12 hours, 3-hour infusion), and etoposide ([VP... Transfusion requirements of 477 patients with hematologic malignancies undergoing BMT from HLA-identical siblings were studied. The Royal Marsden Cancer Charity raises money solely to support The Royal Marsden. Dr. He is Director of the Stem Cell Laboratory of the Barts Health NHS Trust, and has an interest in diagnostic immunophenotyping. New Delhi metallo-beta-lactamase 1. The Royal Marsden Medical Directors Support Day 4 Dr Ros Taylor @hospicedoctor 5 The Royal Marsden The Royal Marsden. SPS developed in 31 patients a median of 10 months after transplantation (range, 3 to 187 months). Addressed mainly to the Nursing Profession He has research interests in stereotactic and image-guided radiotherapy, risk prediction in early prostate cancer, and functional MRI. All rights reserved. … Coronavirus (COVID-19): visiting The Royal Marsden suspended . Here we report the response to IS therapy of 111 patients with AA and correlate this with GPI-anchored protein expression on peripheral... A woman with Philadelphia chromosome-positive c-ALL with +8 and i17q in addition underwent an unpurged blood stem cell autograft after 200mg/m2 melphalan in first relapse. Immune manipulation comprised donor leukocyte infusion (n=18), interfero... Red cell fragmentation is often the earliest sign of thrombotic microangiopathy. Dr Susana Banerjee is a Consultant Medical Oncologist at the Royal Marsden specialising in the treatment of patients with ovarian cancer and other gynaecological cancers. With dedicated units for all cancer types, The Royal Marsden provides care during diagnosis, treatment and beyond, and has specialist paediatric facilities for children and young people. Official information from NHS about The Royal Marsden Hospital (Surrey) including contact details, directions, opening hours and service/treatment details. Find contact's direct phone number, email address, work history, and more. About us . Article. Skilled in Clinical Research, Medical Education and Laparoscopic/Robotic Surgery. This trust provides Oncology - Medical at 2 hospital(s) Please note: this consultant may not be available at all these locations. A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Each type of blood cancer requires a different approach. CAR T-cells and Cellular Therapy London. Viral haemorrhagic cystitis (HC) is a significant complication after haematopoietic stem cell transplantation (HSCT), with a potential for major morbidity. We offer proven treatments including cytotoxic chemotherapy, immunotherapy (such as antibodies that bind to and kill malignant cells), enzyme inhibiting drugs (such as tyrosine kinase inhibitors) and bone marrow transplantation. Sorry, you need to be a researcher to join ResearchGate. Patients with haematological malignancies receiving intensive chemotherapy and requiring hospitalization were randomized in a double-blind... A retrospective case-matched study was conducted to compare the oral regimen CTD (cyclophosphamide - thalidomide - dexamethasone) and infusional CVAMP (cyclophosphamide - vincristine - doxorubicin - methylprednisolone) as induction therapy followed by autologous peripheral blood stem-cell transplantation (PBSCT) for newly diagnosed multiple myeloma... Lenolidamide (Revlimid®) is an oral immunomodulatory drug that has been shown to be effective for the treatment of relapsed refractory myeloma, and in-vitro laboratory studies suggest that its action may be synergistic with a number of conventional chemotherapeutic agents. 31, 49-50. The median nucleated (7.0 vs 3.2 x 10(8)/kg; P < 0.000... Of 1774 patients with breast cancer given mitoxantrone (MTZ) with methotrexate (n = 492) or with methotrexate and mitomycin C (n = 1282), nine developed MDS/AML after a median of 2.5 years. This was in all likelihood a manifestation of chronic graft-versus-host disease (cGVHD), although the patient has no other stigmata of this and suffered little acute graft-versus-host disease (aGVHD) after BMT. He worked in … She then held positions with the Institute of Cancer Research and the Royal Marsden Hospital, both in London, prior to moving to the USA. It is not known if donor-recipient ABO blood group incompatibility contributes to graft-versus-leukemia after allogeneic BMT. Access Dr's Contact Information . THE ROYAL MARSDEN Disclosure • Advisory Board: Eli-Lilly, Bristol Meyers Squibb, MSD, Bayer, Roche, Merck-Serono, Astra-Zeneca • Research funding: Eli-Lilly, Janssen-Cilag, Sanofi Oncology, Merck-Serono • Honorarium: Eli-Lilly, Five Prime Therapeutics. Mr S Saso, Subspecialty Trainee, Imperial College NHS Trust 1530-1540: Break 1530-1600: Clinical Genetics in Gynaecological Oncology Dr A George, Consultant, Royal Marsden Hospital 1600-1630: Genetic Counseling in Gynaecological Oncology Ms C Moss, Genetic Counselor, Royal Marsden Hospital Registration: Anoop P, Shaw BE, Riley U, Ethell ME, Taj M, Lancaster DL, Atra A, Saso R, Littlewood S, Mohammed K, Davies F, Treleaven J, Morgan GJ, Potter MN. Please see more information here about how we are keeping everyone safe. Regression models ... Royal Marsden Hospital, Sutton, UK . The overall i... 1348 Please see more information here about how we are keeping everyone safe. MijelomCRO je na susretu u Amsterdamu podijelila informacije o … The Royal Marsden’s Haemato-oncology Unit is one of the largest in Europe, diagnosing, treating and researching blood cancers in adults and children. Please see more information here about how we are keeping everyone safe. Last Update. Coronavirus (COVID-19): visiting The Royal Marsden suspended . Barbara J Bain. Dr R. Saso’s HQ phone number is (605) 716-3200 What is Dr R. Saso’s latest job experience? S godišnjeg skupa Global Myeloma Action Network. Teaching Cases from the Royal Marsden and St Mary's Hospitals. For the Royal Marsden deputy chief executive Liz Bishop, nursing is in the blood. Menu. The development of an International Prognostic Scoring System (IPSS) based on bone marrow blast percentage, degree of cytopenia and karyotype has allowed the widespread application of the IPSS to guide therapy in patients with MDS. Join to Connect The Royal Marsden NHS Foundation Trust. The cumulative 5-year incidences of relapse and transplant-related mortality were 37 a... Thalidomide was used to treat acute (n=21) or chronic (n=59) graft-vs-host disease (GVHD) in 80 haematopoietic stem cell allograft recipients after failure to respond to the combination of cyclosporine and corticosteroids with or without other agents. He leads the myeloma team at UHS with direct responsibility for clinical management of myeloma and paraprotein-related disorders including AL amyloidosis and POEMS syndrome. Coronavirus (COVID-19) latest: Visiting The Royal Marsden is still suspended, but we want to reassure our patients, their families and anyone worried about cancer during this difficult time that we are still delivering treatment - the hospital is open. This disorder is often retrospectively diagnosed--at 7 cases from our study. Clin Transplant 2011: 25: 222–227. dr. Lejla Ibričević iz UKC Sarajevo i Nerma Mrđanović, predstavnica udruge Mijelom u BiH. The aim of this 7-year analysis of 1160 HSCT patients was to evaluate risk factors for the incidence, severity, toxicity of therapy, clinical course, and outcome of this condition. This model is based on an intention to treat analysis of 383 patients with previously untreated myeloma, their responses to induction chemotherapy and to intensive high dose melphalan (HDM). Sirohi B. Some authors have suggested that RIC allo-SCT be performed entirely in the outpatient setting. We believe research is one of the key factors in improving patient outcomes. Dr Saso. Export . Cox DR . He was a winner of the NHS Innovator Award in 2006 for the introduction of new … https://www.icr.ac.uk/our-research/researchers-and-teams/dr-martin-kaiser 6/27/2019 5:08 AM. If standard infusional therapy (IC) has been used to treat myeloma at presentation, it is a matter of debate whether patients should receive the original induction therapy or a different drug combination in first relapse. Treatment of relapsed and refractory multiple myeloma in the era of novel agents Dr Sarah Coleman Clinical Psychologist at the Royal Marsden Foundation Trust/ Private psychologist at Efficacy Victoria London, Greater London, United Kingdom 115 connections Secondary myelodysplastic syndrome/acute myeloid leukaemia following mitoxantrone-based therapy for breast carcinoma, Chronic graft versus host is associated with long-term risk for pneumococcal infections in recipients of bone marrow transplant, Chronic graft versus host disease is associated with long-term risk for pneumococcal infections in recipients of bone marrow transplants, Acute lymphoblastic leukaemia-type intensive chemotherapy to eliminate minimal residual disease after high-dose melphalan and autologous transplantation in multiple myeloma - A phase I/II feasibility and tolerance study of 17 patients, Melphalan/TBI is not more carcinogeneic than cyclophosphamide/TBI for transplant conditioning: Follow-up of 725 patients from a single centre over a period of 26 years, Comparison of marrow and blood cell yields from the same donors in a double-blind, randomized study of allogeneic marrow vs blood stem cell transplantation, Increased risk of secondary mds/aml in patients treated for hodgkin disease, Single center evaluation of acute monocytic leukaemia (aml-m5), Collection of peripheral blood stem cells in newly-diagnosed myeloma patients without any prior cytoreductive therapy, Complete remission rate and outcome after intensive treatment of 177 patients under 75 years of age with IgG myeloma defining a circumscribed disease entity with a new staging system, The Impact of Karyotype on Remission Rates in Adult Patients with de novo Acute Myeloid Leukemia Receiving High-Dose Cytarabine-Based Induction Chemotherapy, Recombinant tissue plasminogen activator (rtPA) for the treatment of hepatic veno-occlusive disease (VOD), Impact of previous high-dose therapy on outcome after allografting for multiple myeloma, Vaginal stenosis following allogeneic bone marrow transplantation for acute myeloid leukemia, Bone marrow transplants for paroxysmal nocturnal haemoglobinuria, Long-Term Follow-Up of Relapsed Acute Leukemia Treated with Immunotherapy After Allogeneic Transplantation: the Inseparability of Graft-Versus-Host Disease and Graft-Versus-Leukemia, and the Problem of Extramedullary Relapse, Red cell fragmentation (schistocytosis) after bone marrow transplantation, Secondary leukaemia characterised by monosomy 7 occurring post-autologous stem cell transplantation for AML, Deficiency of glycosylphosphatidyl inositol-anchored proteins in patients with aplastic anaemia does not affect response to immunosuppressive therapy, Therapy of acute megakaryocytic leukaemia (AML-M7), Biphenotypic leukaemia: Eight year experience from a single centre, Immunophenotypic and cytogenetic features in patients with minimally differentiated acute myeloid leukaemia (AML-M0), Factors affecting blood component requirement after autograft for haematological malignancies. Hospital … The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor. Treatment decisions are made after a careful review of the diagnosis and staging tests at disease-specific multi-disciplinary team meetings. Between March 1973 and August 2003, 747 patients (M: 430, F:317; median age: 29yr, range:1–65) who survived for at least 1 yr. post stem cell transplant and were 15 to 65 years of age (median: 38, range:15–71) at the time of last follow-up (LFU) were analysed to study the incidence and outcome of pregnancies. Coronavirus (COVID-19): visiting The Royal Marsden suspended . Moreno L, Bautista FJ, Zacharoulis S. Childs Nerv Syst. Sign Up. Bone marrow transplant (BMT) was performed in 191 patient, while 684 patients had peripheral blood stem cell transplant (SCT). Nationally recognised as the definitive guide to clinical nursing skills, The Royal Marsden Manual of Clinical Nursing Procedures has provided essential nursing knowledge and up-to-date information on nursing skills and procedures for over 30 years. Other ri... Paroxysmal nocturnal haemoglobinuria (PNH) is a rare clonal haematological disorder characterized by intravascular haemolysis and increased risk of thrombosis. We examined lymphocyte counts as a surrogate marker of immune... Myelodysplastic syndrome is a heterogenous clonal disorder stemming from an insult at the progenitor cell level. August 1, 2019 August 13, 2019 admin Aktivnosti. Natalie Barnfield. The Royal Marsden’s Haemato-oncology Unit is one of the largest in Europe, diagnosing, treating and researching blood cancers in adults and children. Search. Natalie Barnfield Darzi Fellow at The Royal Marsden NHS Foundation Trust London. Dr Rao completed medical training at Charing Cross and Westminster Medical School and specialist oncology training at The Royal Marsden. Lenolidamide (Revlimid), in Combination with Cyclophosphamide and Dexamethasone (CRD) Is an Effective Regimen for Heavily Pre-Treated Myeloma Patients. Coronavirus (COVID-19): visiting The Royal Marsden suspended . In Multiple Myeloma Bone Disease healthy bone remodelling is affected by tumour cells by means of paracrine cytokinetic signalling in such a way that osteoclast formation is enhanced and the growth of osteoblast cells inhibited. To date clinical observations on EM myeloma are based on small series of relapsed patients and results suggest that the disease cou... Blastoid morphology is a rare presenting feature of myeloma which is frequently seen in patients with extramedullary myeloma and is associated with poor clinical outcome. The Royal Marsden Manual of Clinical Procedures Ninth Edition. Sheela RAO, Consultant of The Royal Marsden NHS Foundation Trust, London | Read 188 publications | Contact Sheela RAO Dr at The Royal Marsden NHS Foundation Trust Sutton, United Kingdom 20 connections. Consultant Hepatobiliary and Robotic surgeon at the world renowned Royal Marsden Hospital. Coronavirus (COVID-19) latest: Visiting The Royal Marsden is still suspended, but we want to reassure our patients, their families and anyone worried about cancer during this difficult time that we are still delivering treatment - the hospital is open. GVHD... We correlated age and body surface area corrected glomerular filtration rate (GFR) at the time of high-dose melphalan (HDM) administration with treatment-related toxicity (TT), time to disease progression and survival. Sequential Development of Myelodysplasia and Acute Myeloid Leukemia but with no Karyotypic Evolution after Autografting in a Patient with Philadelphia Positive Acute Lymphoblastic Leukemia, How Erythropoietin Affects Bone Marrow of Uremic Patients, Idarubicin, high-dose cytarabine, and etoposide for induction of remission in acute leukemia, Transfusion requirements after bone marrow transplantation from HLA-identical siblings: Effects of donor-recipient ABO incompatibility. Menu Close menu. Dr Banerjee graduated with a first class from St John’s College, University of Cambridge, and completed her medical training at Royal Free Medical School where she was a University of London Gold Medal finalist. At the time of transplantation, 138 pat... Bortezomib (Velcade®), as the first-in-class proteasome inhibitor, has shown to be effective for the treatment of relapsed refractory myeloma. Seventy-five (16.3%) patients with EM involvement at diagnosis were compared with 384 cases without EM disease. 2. Two groups were well matched for transplant and demographic characters and all received CyA amd Mix for GVHD prophylaxis. MC, a component of standard ALL therapy, is usually not employed after autografting. Secondary leukaemia has rarely been reported as a complication of autologous stem cell transplantation for AML. It is known to be safe and effective in presumed and confirmed fungal infections in immunocomprom... ABCD consists of amphotericin and sodium cholesteryl sulfate in a 1:1 molar ratio. Haemato-oncology Unit: information for healthcare professionals, Dr Radovan Saso, Associate Specialist in Haematology, Go to Haemato-oncology Unit: information for healthcare professionals, Our free GP Education Days and how to register, Dr Martin Kaiser, Consultant Haematologist, Dr Claire Dearden, Consultant Haematologist, Dr Sunil Iyengar, Consultant Haematologist, Dr Dima El-Sharkawi, Consultant Haematologist, Dr David Taussig, Consultant Haematologist, Dr Mike Potter, Director of Bone Marrow Transplantation and Consultant Haematologist​, Dr Emma Nicholson, Consultant in Haematology and Bone Marrow Transplantation, Dr Simon O'Connor, Consultant Haematopathologist, Dr Andrew Wotherspoon, Consultant Haematopathologist, acute myeloid leukaemia and myelodysplastic syndrome, chronic myeloid leukaemia and related disorders, chronic lymphocytic leukaemia and related disorders, histopathology to look at tissue biopsies at the microscopic level, cytogenetics to look for chromosomal changes in cancer cells, immunophenotyping to look at proteins on the surface of cancer cells. University students and faculty, institute members, and independent researchers, Technology or product developers, R&D specialists, and government or NGO employees in scientific roles, Health care professionals, including clinical researchers, Journalists, citizen scientists, or anyone interested in reading and discovering research. Dr Mark Ethell, Consultant in Haematology and Bone Marrow Transplantation, Dr Chloe Anthias, Consultant in Haematology and Bone Marrow Transplantation, Dr Sandra Easdale, Locum Consultant in Haematology and Bone Marrow Transplantation, Dr Ayoma Attygalle, Consultant Haematopathologist, Dr Corinne De Lord, Consultant Haematologist, Kim Davis, Haemato-Oncology Research Sister, Joy Brennan, Stem Cell Transplant Co-ordinating Sister, Maria Mulligan, Stem Cell Transplant Co-ordinator, Hayley Leonard, Anthony Nolan Post-Transplant Nurse Specialist, Mucha Mupanemunda, Leukaemia Nurse Specialist, Sharon West, Haemato-oncology Advanced Nurse Practitioner, Carmela (Ella) Panlaqui, Myeloma Nurse Specialist, Michelle Harris, Lymphoma Nurse Specialist, Lucy Whiteman, Lymphoma/CLL Nurse Specialist, Kathryn Chandler, Lymphoma Nurse Specialist, Jane Howes, Haemato-oncology Clinical Nurse Specialist, Sarah Thompson, Haemato-oncology Advanced Nurse Practitioner, Richard Spencer, Haemato-oncology Advanced Nurse Practitioner. The development of high dose melphalan and of autologous bone marrow transplantation in the treatment of multiple myeloma: Royal Marsden and St Bartholomew's Hospital studies. Does donor-recipient ABO incompatibility protect against relapse after allogeneic bone marrow transplantation in first remission acute myeloid leukemia? Early high resolution computed tomography (HRCT) scans allow for prompt diagnosis and more efficacious treatment of invasive pulmonary aspergillosis (IPA) in immunocompromised patients with haematologic malignancies. The median leukocyte and platelet count at presentation were 16.5x109/1 (range:1.7-391) and 124 x 109/1 (range:7-427) respectively. Bhawna Sirohi, Samar Kulkarni, Ray Powles, Some early phase II trials in previously untreated multiple myeloma: The royal marsden experience, Seminars in Hematology, 10.1016/S0037-1963(01)90012-5, 38, 3, (209-218), (2001). Between 8/85 and 6/98, 144 newly diagnosed myeloma patients with a median age of 53 years (range, 31-72) received infusional chemot... Of the 61 newly diagnosed patients with Bence-Jones (BJ) myeloma presenting to our centre between May 1986 and December 1997, 53 received sequential therapy (ST) comprising infusional chemotherapy (IC) followed by high-dose therapy and autotransplantation with interferon-alpha2b maintenance. Coronavirus (COVID-19) latest: Visiting The Royal Marsden is still suspended, but we want to reassure our patients, their families and anyone worried about cancer during this difficult time that we are still delivering treatment - the hospital is open. E‐mail: estela.matutes@aehh.org. 2009 Sep;25(9):1047-52. May 2004; Michael Gattens. The Royal Marsden NHS Foundation Trust ... Kulkarni S, Saso R, Evans S, Treleaven J, Davies FE, Ethell ME, Morgan GJ, Potter MN. Please see more information here about how we are keeping everyone safe. We conducted a retrospective study... From August 1973 to December 2003, 1651 patients (median age: 28yr., range: 1–74 yr.; M: 982, F: 669) received stem cell transplants for haematological malignancies (Ac. HQ Phone (605) 716-3200. Coping with hydrological extremes (Mitigation and Adaptation Strategies for Global Change (2003) 7:3). Sirohi, B. Powles, R. Singhal, S. Treleaven, J. Horton, C. Tait, D. Kulkarni, S. Saso, R. Mehta, J. Low-dose amphotericin B lipid complex (ABLC) is safe and effective as empiric anti-fungal therapy in immunocompromised patients with hematologic malignancies. We report two cases of AML who presented with well-characterised cytogenetic abnormalities at presentation: t(8;21) and t(15;17) respectively, and who, after achieving complete morphological and cytogenetic remissions post-autograft, deve... Deficient expression of glycosylphosphatidyl inositol (GPI)-anchored proteins in aplastic anaemia (AA) patients has previously been reported to be associated with a poor response to immunosuppressive (IS) therapy. About us . Personal experience with 11 cases]. 2010. At these meetings, a range of experts come together to finalise a treatment plan for each individual patient. The purpose of the study was to determine the role of sequential therapy (ST) in new patients with myeloma presenting with renal dysfunction (RD): serum creatinine >140 µmol/L (1.6 mg/dL). Email Finder Top Companies Company Search People Search Solutions About Us. Coronavirus (COVID-19): visiting The Royal Marsden suspended . The probabil... Incidences of and risk factors for Streptococcus pneumoniaesepsis (SPS) after hematopoietic stem cell transplantation were analyzed in 1329 patients treated at a single center between 1973 and 1997. (2001).Melphalan-total body irradiation and allogeneic transplantation from HLA-identical siblings for acute myeloid leukemia in first remission: Higher relapse after marrow-derived stem cell grafts compared to blood despite similar chronic graft-versus-host disease. Please see more information here about how we are keeping everyone safe. MijelomCRO je na susretu u Amsterdamu podijelila informacije o uvrštenju pametnih lijekova na … At The … Na susretu će govoriti Ljiljana Pomer, predstavnica udruge MijelomCRO, dr. Radovan Saso iz bolnice Royal Marsden u Londonu, zatim doc. Home Health A-Z Live Well Care and support Pregnancy NHS services The Royal Marsden Hospital (Surrey) 020 8642 6011 … All patients received rtPA at a dose of 10 mg/day as a starting dose, an... We describe a single centre experience of 33 patients allografted for multiple myeloma, of which 28 received matched sibling marrow, one haploidentical family donor marrow and four matched but unrelated donor marrow. Days +14, +28 and +42 blood films from 58 allograft and 32 autograft recipients were reviewed blind to determine the incidence and severity of schistocytosis (the number of fragmented red cells per 1000 red cells expressed as a percentage). Background View Dr Saso's business profile at Care Oncology LLC. Dr. Davies is a Professor of Medicine and Deputy Director of the … Vallari Shah. Royal Marsden Hospital and the Institute of Cancer Research, Sutton, UK . Skip to main content NHS homepage. 173 patients referred at relapse after previous treatment elsewhere were excluded and a cohort of 734 patients diagnosed and treated at RMH (M/F: 448/286; median age: 28 y. range: 4-81) were analysed for a risk of developing secondary MDS/ A... Twenty patients (M 14, F 6; 1-69 years, median 28) with AML-M5 were treated at this hospital between 1990-99. Donor was allogeneic (n=1088), autologous (n=537) or syngeneic (n=26) and conditioning was with (n=1243) or without TBI (n=408). The median progression free survival (PFS) for younger, fitter patients with multiple myeloma is between 3 and 4 years, however some patients respond very poorly and relapse within a year of autologous transplantation. rtPA was started a median of 13 days post transplant (range 4-35). Impact of cytogenetics on the outcome of autotransplantation for acute myeloid leukemia in first remission: Is the benefit of intensive pretransplant therapy limited to patients with good karyotypes? Sirohi B. Splenomegaly is the main clinical manifestation,... Join ResearchGate to find the people and research you need to help your work. Re-use of the original infusional induction chemotherapy as salvage therapy in myeloma patients relapsing after one autograft, An elective single autograft with high-dose melphalan: Single-center study of 451 patients, Long-term outcomes of previously untreated myeloma patients: Responses to induction chemotherapy and high-dose melphalan incorporated within a risk stratification model can help to direct the use of novel treatments, The role of second autografts in the long term management of myeloma: Disease characteristics at relapse are predictive of response and can guide therapeutic decisions. Patients staying overnight will normally stay on the Bud Flanagan Wards at our Sutton hospital. The crude incidence of developing MDS/AML after MMM or MM chemotherap... Incidences of and risk factors for Streptococcus pneumoniae sepsis (SPS) after hematopoietic stem cell transplantation were analyzed in 1329 patients treated at a single center between 1973 and 1997. Search for more papers by this author. He was a winner of the NHS Innovator Award in 2006 for the introduction of new … He had been apprenticed to a pharmacist in Sheffield, and defied his father’s wishes to take up a partnership by moving to London where he trained as a physician. Research breakthroughs, new facilities and staff appointments. Share . In all, 451 myeloma patients, 51% previously untreated, underwent elective single autotransplantation after 200 mg/m(2) melphalan between 1985 and 2001 at the Royal Marsden Hospital. Between Aug/64 and Jun/00 909 patients were registered on a prospectively maintained Lymphoma unit database. Diagnosis was made on the basis of FAB criteria. Skip to main content NHS homepage. With your help we can continue to be there for everyone who needs us. Osteoclast-induced myeloma cell growth is also reported. Collection of peripheral blood stem cells in newly diagnosed myeloma patients without any prior cytoreductive therapy: The first step towards an 'operational cure'? Hematol Oncol. The frequency of this disorder is 2.5% from all leukemias. Dr Justin Grayer Principal Psychologist/ Team Lead at The Royal Marsden NHS Foundation Trust London, United Kingdom 396 connections

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